Immunotherapy candidate for multiple cancers
CV301 is an immunotherapy candidate that targets two tumor-associated antigens, CEA and MUC-1, long known to be overexpressed in major cancer types. Preclinical data shows that CV301 upregulates PD-L1 by mounting an immune response against a tumor target. The upregulation of PD-L1 is a marker indicating the tumor is under attack from T-cells, presenting an opportunity for a greater response in patients who might otherwise not benefit from treatment with a checkpoint inhibitor alone.
The development of CV301 focuses on combination treatments with other immune-modulating agents such as checkpoint inhibitors as the understanding in the disease pathophysiology evolves with respect to the immune system. The options for modulation of the immune system for cancer treatment are increasing and the development of CV301 will also evolve to take advantage of these options. From a functional standpoint, CV301 has the potential to be combined with most cancer immune modulators. We believe CV301 equips the immune system with the ability to seek out and destroy tumor cells.
CEA and MUC-1 overexpression in selected cancers
|Bladder cancer||60% - 75%||>90%|